Article

A unique subset of pericystic endothelium associates with aberrant microvascular remodelling and impaired blood perfusion early in polycystic kidney disease

2024-03-06

Abstract excerpt

<h4>ABSTRACT</h4> Hallmarks of autosomal dominant polycystic kidney disease (ADPKD), the most common hereditary kidney anomaly, include expanding fluid-filled epithelial cysts, inflammation, and fibrosis. Despite previous work showing the potential of vascular-based therapies, renal microvascular alterations in ADPKD, and their timing, are poorly understood. Using single-cell transcriptomics of human kidney micro...

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Literature Corpus work: 9aa642fc-236a-5e49-a18b-0d089e69c49a
DOI: 10.1101/2024.03.03.583132

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