Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PQM-1 controls hypoxic survival via regulation of lipid metabolism.

Nature communications - 2 Oct 2020

Heimbucher Thomas, Hog Julian, Gupta Piyush, Murphy Coleen T

Abstract excerpt

Animals have evolved responses to low oxygen conditions to ensure their survival. Here, we have identified the C. elegans zinc finger transcription factor PQM-1 as a regulator of the hypoxic stress response. PQM-1 is required for the longevity of insulin signaling mutants, but surprisingly, loss of PQM-1 increases survival under hypoxic conditions. PQM-1 functions as a metabolic regulator by controlling oxygen...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans Proteins
Share to Embryo, Mammalian
Share to Glycogen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia

Share to Lipid Metabolism

Share to Oxygen Consumption

Share to Stress, Physiological

Source

Open in PubMed Open full text

Identifiers

PMID: 33009389
DOI: 10.1038/s41467-020-18369-w
PMCID: PMC7532158

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PQM-1 controls hypoxic survival via regulation of lipid metabolism.PMID 33009389Read ↗

FNDC-1-mediated mitophagy and ATFS-1 coordinate to protect against hypoxia-reoxygenationSemantic proximity Read ↗

Regulation of fatty acid desaturase- and immunity gene-expression by mbk-1/DYRK1A in Caenorhabditis elegansSemantic proximity Read ↗

Life-span extension from hypoxia in Caenorhabditis elegans requires both HIF-1 and DAF-16 and is antagonized by SKN-1.Semantic proximity Read ↗

Mitochondrial bioenergetics deficiency in cisd-1 mutants is linked to AMPK-mediated lipid metabolism.Semantic proximity Read ↗

C30F12.4 influences oogenesis, fat metabolism, and lifespan in C. elegans.Semantic proximity Read ↗

The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans.Semantic proximity Read ↗

Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK compromised C. elegans dauer larvae.Semantic proximity Read ↗

Oocyte mitochondria link maternal environment to offspring phenotypeSemantic proximity Read ↗

XBP-1 Remodels Lipid Metabolism to Extend LongevitySemantic proximity Read ↗

Mutation of the lbp-5 gene alters metabolic output in Caenorhabditis elegans.Semantic proximity Read ↗

DAF-16 and TCER-1 Facilitate Adaptation to Germline Loss by Restoring Lipid Homeostasis and Repressing Reproductive Physiology in C. elegans.Semantic proximity Read ↗

The F-box protein FBXL-5 governs vitellogenesis and lipid homeostasis in <i>C. elegans</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.