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Article

SARS-CoV-2 samples may escape detection because of a single point mutation in the N gene.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin - 1 Oct 2020

Ziegler Katharina, Steininger Philipp, Ziegler Renate, Steinmann Jörg, Korn Klaus, Ensser Armin

Abstract excerpt

We found that a single nucleotide polymorphism (SNP) in the nucleoprotein gene of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from a patient interfered with detection in a widely used commercial assay. Some 0.2% of the isolates in the EpiCoV database contain this SNP. Although SARS-CoV-2 was still detected by the other probe in the assay, this underlines the necessity of targeting two independent...

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Identifiers

PMID: 33006300
DOI: 10.2807/1560-7917.ES.2020.25.39.2001650
PMCID: PMC7531073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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