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SARS-CoV-2 N gene mutations impact detection by clinical molecular diagnostics: reports in two cities in the United States.

Diagnostic microbiology and infectious disease - 1 Nov 2021

Leelawong Mindy, Mitchell Stephanie L, Fowler Randal C, Gonzalez Edimarlyn, Hughes Scott, Griffith Marissa P, Marsh Jane W, Harrison Lee H, Rakeman Jennifer L

Abstract excerpt

Nasal and nasopharyngeal swab specimens tested by the Cepheid Xpert Xpress SARS-CoV-2 were analyzed by whole-genome sequencing based on impaired detection of the N2 target. Each viral genome had at least one mutation in the N gene, which likely arose independently in the New York City and Pittsburgh study sites.

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Identifiers

PMID: 34425451
DOI: 10.1016/j.diagmicrobio.2021.115468
PMCID: PMC8255188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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