Article

Ependymal cell maturation is heterogeneous and ongoing in the mouse spinal cord and dynamically regulated in response to injury

2022-03-08

Abstract excerpt

<h4>Summary</h4> The spinal cord neural stem cell potential resides within the ependymal cells lining the central canal. These cells are, however, heterogeneous, and we know little about the biological diversity this represents. Here we use single-cell RNA-sequencing to profile adult mouse spinal cord ependymal cells. We uncover transcriptomes of known subtypes and a new mature ependymal cell state, that becomes...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 500de43c-c626-50e6-8d93-dd8b6c2e1787
DOI: 10.1101/2022.03.07.483249

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ependymal cell maturation is heterogeneous and ongoing in the mouse spinal cord and dynamically regulated in response to injuryDOI 10.1101/2022.03.07.483249Read

Persistence of FoxJ1 <sup>+</sup> Pax6 <sup>+</sup> Sox2 <sup>+</sup> ependymal cells throughout life in the human spinal cordSemantic proximity Read

Decoding spatiotemporal gene expression of the developing human spinal cord and implications for ependymoma originSemantic proximity Read

Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cordSemantic proximity Read

Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCsSemantic proximity Read

General and cell-type-specific aspects of the motor neuron maturation transcriptional programSemantic proximity Read

Single cell transcriptome profiling of the human developing spinal cord reveals a conserved genetic programme with human specific featuresSemantic proximity Read

Diversity of Adult Neural Stem and Progenitor Cells in Physiology and DiseaseSemantic proximity Read

High resolution mouse subventricular zone stem cell niche transcriptome reveals features of lineage, anatomy, and agingSemantic proximity Read

Long-lasting structural and functional maturation in transplanted human neurons reprogrammed from glial progenitor cellsSemantic proximity Read

A MOUSE ORGANOID PLATFORM FOR MODELING CEREBRAL CORTEX DEVELOPMENT AND CIS-REGULATORY EVOLUTION IN VITROSemantic proximity Read

A comprehensive view of cell-type-specific temporal dynamics in human and mouse brainsSemantic proximity Read

Single-cell RNA-seq reveals dynamic transcriptome profiling in human early neural differentiationSemantic proximity Read