Comprehensive genetic analysis of pediatric germ cell tumors identifies potential drug targets.

doi:10.1038/s42003-020-01267-8

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Comprehensive genetic analysis of pediatric germ cell tumors identifies potential drug targets.

Communications biology - 30 Sept 2020

Kubota Yasuo, Seki Masafumi, Kawai Tomoko, Isobe Tomoya, Yoshida Misa, Sekiguchi Masahiro, Kimura Shunsuke, Watanabe Kentaro, Sato-Otsubo Aiko, Yoshida Kenichi, Suzuki Hiromichi, Kataoka Keisuke, Fujii Yoichi, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Hiwatari Mitsuteru, Oka Akira, Hayashi Yasuhide, Miyano Satoru, Ogawa Seishi, Hata Kenichiro, Tanaka Yukichi, Takita Junko

Abstract excerpt

To elucidate the molecular pathogenesis of pediatric germ cell tumors (GCTs), we performed DNA methylation array analysis, whole transcriptome sequencing, targeted capture sequencing, and single-nucleotide polymorphism array analysis using 51 GCT samples (25 female, 26 male), including 6 germinomas, 2 embryonal carcinomas, 4 immature teratomas, 3 mature teratomas, 30 yolk sac tumors, and 6 mixed germ cell tumors....

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Identifiers

PMID: 32999426
DOI: 10.1038/s42003-020-01267-8
PMCID: PMC7528104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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