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DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors

27 Jun 2013

Abstract excerpt

BACKGROUND: Aberrant DNA methylation is a prominent feature of many cancers, and may be especially relevant in germ cell tumors (GCTs) due to the extensive epigenetic reprogramming that occurs in the germ line during normal development. METHODS: We used the Illumina GoldenGate Cancer Methylation Panel to compare DNA methylation in the three main histologic subtypes of pediatric GCTs (germinoma, teratoma and yolk...

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PMID: 23806198
DOI: 10.1186/1471-2407-13-313

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