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Article

Epigenetic activation of the small GTPase TCL contributes to colorectal cancer cell migration and invasion

30 Sept 2020

Abstract excerpt

TC10-like (TCL) is a small GTPase that has been implicated in carcinogenesis. Elevated TCL expression has been observed in many different types of cancers although the underlying epigenetic mechanism is poorly understood. Here we report that TCL up-regulation was associated with high malignancy in both human colorectal cancer biopsy specimens and in cultured colorectal cancer cells. Hypoxia, a pro-metastatic...

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PMID: 32999272
DOI: 10.1038/s41389-020-00269-9

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