Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypoxia promotes colorectal cancer cell migration and invasion in a SIRT1-dependent manner

30 Apr 2019

Abstract excerpt

BACKGROUND: Hypoxic microenvironments play a significant role in the progression of colorectal cancer (CRC). Silencing information regulator 1 (SIRT1), a class III histone deacetylase, modulates the multiple biological behaviors of cancer. However, its role in CRC remains unclear. This study aims to explore the role of SIRT1 in CRC migration and invasion under hypoxia. METHODS: ). The migration and invasion...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Cancer, Hypoxia, and Metabolism
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31068761
DOI: 10.1186/s12935-019-0819-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypoxia promotes colorectal cancer cell migration and invasion in a SIRT1-dependent mannerPMID 31068761Read ↗

SIRT1: a novel regulator in colorectal cancerSemantic proximity Read ↗

High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patientsSemantic proximity Read ↗

Narrower insight to SIRT1 role in cancer: A potential therapeutic target to control epithelial–mesenchymal transition in cancer cellsSemantic proximity Read ↗

SIRT1 promotes the progression and chemoresistance of colorectal cancer through the p53/miR-101/KPNA3 axisSemantic proximity Read ↗

SIRT1 promotes EMT, migration and invasion by regulating mTORC1/4E-BP1 in colorectal cancerSemantic proximity Read ↗

SIRT1 as a masterful reciprocal regulator of molecular mechanisms and signaling pathways involved in tumor growth and expansionSemantic proximity Read ↗

Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinomaSemantic proximity Read ↗

FOXQ1-mediated SIRT1 upregulation enhances stemness and radio-resistance of colorectal cancer cells and restores intestinal microbiota function by promoting β-catenin nuclear translocationSemantic proximity Read ↗

Overexpression of Sirt6 is a novel biomarker of malignant human colon carcinomaSemantic proximity Read ↗

The NR3C2-SIRT1 signaling axis promotes autophagy and inhibits epithelial mesenchymal transition in colorectal cancerSemantic proximity Read ↗

Factor inhibiting HIF1α (FIH-1) functions as a tumor suppressor in human colorectal cancer by repressing HIF1α pathwaySemantic proximity Read ↗

SIRT1 promotes proliferation and inhibits apoptosis of human malignant glioma cell linesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.