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Article

RUNX1 regulates TGF-β induced migration and EMT in colorectal cancer

4 Aug 2020

Abstract excerpt

Colorectal cancer (CRC) was one of the most malignant tumors worldwide due to its metastasis. Epithelial-to-mesenchymal transition (EMT) plays an important role in CRC migration, and transforming growth factor-β (TGF-β) works as a dominating cytokine in CRC EMT process. Here, we originally identified RUNX1 as an important factor among TGF-β induced EMT in CRC. We found that RUNX1 was overexpressed with the...

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PMID: 32866710
DOI: 10.1016/j.prp.2020.153142

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