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Article

Pharmacogenetic analysis of pediatric patients with acute lymphoblastic leukemia: a possible association between survival rate and ITPA polymorphism.

PloS one - 1 Jan 2012

Kim Hyery, Kang Hyoung Jin, Kim Hyo Jeong, Jang Mi Kyung, Kim Nam Hee, Oh Yongtaek, Han Byoung-Don, Choi Ji-Yeob, Kim Chul Woo, Lee Ji Won, Park Kyung Duk, Shin Hee Young, Ahn Hyo Seop

Abstract excerpt

Genetic polymorphisms are important factors in the effects and toxicity of chemotherapeutics. To analyze the pharmacogenetic and ethnic differences in chemotherapeutics, major genes implicated in the treatment of acute lymphoblastic leukemia (ALL) were analyzed. Eighteen loci of 16 genes in 100 patients with ALL were analyzed. The distribution of variant alleles were CYP3A4*1B (0%), CYP3A5*3 (0%), GSTM1 (21%),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23029095
DOI: 10.1371/journal.pone.0045558
PMCID: PMC3454425

Genes

ITPA
EFS
MTHFR
TPMT
VDR
GSTM1
GSTP1
GSTT1
RFC1
TYMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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