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Article

Impact of genetic polymorphisms on chemotherapy toxicity in childhood acute lymphoblastic leukemia

1 Jan 2012

Abstract excerpt

The efficacy of chemotherapy in pediatric acute lymphoblastic leukemia (ALL) patients has significantly increased in the last 20 years; as a result, the focus of research is slowly shifting from trying to increase survival rates to reduce chemotherapy-related toxicity. At the present time, the cornerstone of therapy for ALL is still formed by a reduced number of drugs with a highly toxic profile. In recent years,...

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PMID: 23189085
DOI: 10.3389/fgene.2012.00249

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