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Article

Efficacy of chemoradiotherapy in pediatric H3K27M-mutant diffuse intrinsic pontine glioma: a study based on single-center and SEER data.

Journal of neuro-oncology - 30 May 2026

Wang Dandan, Liu Xiaohao, Wang Juan, Zhang Boya, Zhai Suna, Xu Jiayao, Wang Long, Zheng Yingjuan, Wei Wei, Zhou Yubing

Abstract excerpt

BACKGROUND: H3K27M-mutant diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brainstem tumor with a median overall survival (OS) of less than one year. Radiotherapy (RT) is the standard treatment, but the survival benefit of adding temozolomide (TMZ) remains controversial. METHODS: Two retrospective cohorts were analyzed. In the single-center cohort (44 patients), patients were divided into three...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42218248
DOI: 10.1007/s11060-026-05622-3
PMCID: PMC13222274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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