Article
Identification of virulence determinants in uropathogenic Proteus mirabilis using signature-tagged mutagenesis.
Journal of medical microbiology - 1 Sept 2008
Himpsl Stephanie D, Lockatell C Virginia, Hebel J Richard, Johnson David E, Mobley Harry L T
Abstract excerpt
The Gram-negative bacterium Proteus mirabilis causes urinary tract infections (UTIs) in individuals with long-term indwelling catheters or those with functional or structural abnormalities of the urinary tract. Known virulence factors include urease, haemolysin, fimbriae, flagella, DsbA, a phosphate transporter and genes involved in cell-wall synthesis and metabolism, many of which have been identified using the...
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