Identification of virulence mutants of the fungal pathogen Cryptococcus neoformans using signature-tagged mutagenesis.

doi:10.1093/genetics/157.3.935

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Article

Identification of virulence mutants of the fungal pathogen Cryptococcus neoformans using signature-tagged mutagenesis.

Genetics - 1 Mar 2001

Nelson R T, Hua J, Pryor B, Lodge J K

Abstract excerpt

Cryptococcus neoformans var. neoformans is an important opportunistic fungal pathogen of patients whose immune system has been compromised due to viral infection, antineoplastic chemotherapy, or tissue transplantation. As many as 13% of all AIDS patients suffer a life-threatening cryptococcal infection at some time during the course of their HIV disease. To begin to understand the molecular basis for virulence in...

Topics

Actins
Animals
Blotting, Northern
Blotting, Southern
Blotting, Western
Chromosome Mapping
Crossing Over, Genetic
Cryptococcus neoformans
Female
Genetic Vectors
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred BALB C

Models, Genetic

Mutagenesis

Mutation

Plasmids

Polymerase Chain Reaction

Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 11238384
DOI: 10.1093/genetics/157.3.935
PMCID: PMC1461580

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-11238384-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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