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Article

Regulation of ER-phagy by a Ypt/Rab GTPase module.

Molecular biology of the cell - 1 Oct 2013

Lipatova Zhanna, Shah Ankur H, Kim Jane J, Mulholland Jonathan W, Segev Nava

Abstract excerpt

Accumulation of misfolded proteins on intracellular membranes has been implicated in neurodegenerative diseases. One cellular pathway that clears such aggregates is endoplasmic reticulum autophagy (ER-phagy), a selective autophagy pathway that delivers excess ER to the lysosome for degradation. Not much is known about the regulation of ER-phagy. The conserved Ypt/Rab GTPases regulate all membrane trafficking...

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Share to Autophagy
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Share to Gene Expression Regulation, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23924895
DOI: 10.1091/mbc.E13-05-0269
PMCID: PMC3784386

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