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Article

CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis.

Developmental cell - 22 Jan 2018

Smith Matthew D, Harley Margaret E, Kemp Alain J, Wills Jimi, Lee Martin, Arends Mark, von Kriegsheim Alex, Behrends Christian, Wilkinson Simon

Abstract excerpt

Mechanisms of selective autophagy of the ER, known as ER-phagy, require molecular delineation, particularly in vivo. It is unclear how these events control ER proteostasis and cellular health. Here, we identify cell-cycle progression gene 1 (CCPG1), an ER-resident protein with no known physiological role, as a non-canonical cargo receptor that directly binds to core autophagy proteins via an LIR motif to...

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Identifiers

PMID: 29290589
DOI: 10.1016/j.devcel.2017.11.024
PMCID: PMC5791736

Genes

CCPG1

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