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Article

Association of the Caveola Vesicular System with Cellular Entry by Filoviruses

15 May 2002

Abstract excerpt

The filoviruses Ebola Zaire virus and Marburg virus are believed to infect target cells through endocytic vesicles, but the details of this pathway are unknown. We used a pseudotyping strategy to investigate the cell biology of filovirus entry. We observed that specific inhibitors of the caveola system, including cholesterol-sequestering drugs and phorbol esters, inhibited the entry of filovirus pseudotypes into...

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PMID: 11967340
DOI: 10.1128/jvi.76.10.5266-5270.2002

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