Article
Molecular classification of pulmonary sarcomatoid carcinomas suggests new therapeutic opportunities.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jul 2017
Pécuchet N, Vieira T, Rabbe N, Antoine M, Blons H, Cadranel J, Laurent-Puig P, Wislez M
Abstract excerpt
BACKGROUND: Pulmonary sarcomatoid carcinoma (SC) is a rare disease with poor prognosis and with strong inter- and intratumor heterogeneity. However, molecular classification is currently focused on activating MET mutations. We sought to better characterize the molecular diversity of SC using mutational signatures that reflect different mutational processes, such as tobacco-associated adducts (signature 4),...
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