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Article

HGF-MET Signaling Shifts M1 Macrophages Toward an M2-Like Phenotype Through PI3K-Mediated Induction of Arginase-1 Expression.

Frontiers in immunology - 1 Jan 2020

Nishikoba Nao, Kumagai Kotaro, Kanmura Shuji, Nakamura Yuko, Ono Mayumi, Eguchi Hiromi, Kamibayashiyama Tomomi, Oda Kohei, Mawatari Seiichi, Tanoue Shiroh, Hashimoto Shinichi, Tsubouchi Hirohito, Ido Akio

Abstract excerpt

Backgrounds and Aims: Hepatocyte Growth Factor (HGF)-MET signaling is known to promote biological functions such as cell survival, cell motility, and cell proliferation. However, it is unknown if HGF-MET alters the macrophage phenotype. In this study, we aimed to study the effects of HGF-MET signaling on the M1 macrophage phenotype. Methods and Materials: Bone marrow-derived macrophages (BMDMs) isolated from mice...

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Identifiers

PMID: 32983173
DOI: 10.3389/fimmu.2020.02135
PMCID: PMC7492554

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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