Article
IL-13Rα1 is a surface marker for M2 macrophages influencing their differentiation and function.
European journal of immunology - 1 Mar 2014
Dhakal Mermagya, Hardaway John C, Guloglu Fatma Betul, Miller Mindy M, Hoeman Christine M, Zaghouani Adam A, Wan Xiaoxiao, Rowland Linda M, Cascio Jason A, Sherman Michael P, Zaghouani Habib
Abstract excerpt
In this study, we examined the role IL-13 receptor alpha 1 (IL-13Rα1) plays in macrophage differentiation and function. The findings indicate that IL-13Rα1 is expressed on the M2 but not on the M1 subset of macrophages and specifically heterodimerizes with the IL-4Rα chain to form a type II receptor, which controls the differentiation and function of these cells. Indeed, BM cells from IL-13Rα1(+/+) and...
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