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Article

Decreased ferroportin in hepatocytes promotes macrophages polarize towards an M2-like phenotype and liver fibrosis.

Scientific reports - 28 Jun 2021

Cai Chengyuan, Zeng Danning, Gao Qing, Ma Lei, Zeng Bohang, Zhou Yi, Wang He

Abstract excerpt

Iron release from macrophages is closely regulated by the interaction of hepcidin, a peptide hormone produced by hepatocytes, with the macrophage iron exporter ferroportin (FPN1). However, the functions of FPN1 in hepatocyte secretion and macrophage polarization remain unknown. CD68 immunohistochemical staining and double immunofluorescence staining for F4/80 and Ki67 in transgenic mouse livers showed that the...

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PMID: 34183746
DOI: 10.1038/s41598-021-92839-z
PMCID: PMC8239022

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