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Article

Hepatocyte growth factor ameliorates dextran sodium sulfate‑induced colitis in a mouse model by altering the phenotype of intestinal macrophages.

Molecular medicine reports - 1 Mar 2023

Fujino Yusuke, Kanmura Shuji, Morinaga Yuko, Kojima Issei, Maeda Nobuhisa, Tanaka Akihito, Maeda Hidehito, Kumagai Kotaro, Sasaki Fumisato, Tanoue Shiroh, Ido Akio

Abstract excerpt

Hepatocyte growth factor (HGF) serves key roles in cell motility, proliferation and immunoregulatory functions. However, the effect of HGF on macrophages is unclear. The present study aimed to elucidate the effect of HGF on the phenotypic alterations of intestinal lamina propria mononuclear cells (LPMCs). Colitis was induced in a mouse model using dextran sodium sulfate (DSS). Subsequently, LPMCs were isolated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36799161
DOI: 10.3892/mmr.2023.12957
PMCID: PMC9942250

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