Pro-inflammatory polarization primes Macrophages to transition into a distinct M2-like phenotype in response to IL-4.

Abstract excerpt

Tissue repair is largely regulated by diverse Mϕ populations whose functions are timing- and context-dependent. The early phase of healing is dominated by pro-inflammatory Mϕs, also known as M1, followed by the emergence of a distinct and diverse population that is collectively referred to as M2. The extent of the diversity of the M2 population is unknown. M2 Mϕs may originate directly from circulating monocytes...

Topics

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• Endothelial Cells
• Interleukin-4
• Macrophages
• Monocytes
• Phenotype