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Article

Detection of gene mutation responsible for Huntington's disease by terahertz attenuated total reflection microfluidic spectroscopy.

Journal of biophotonics - 1 Jan 2021

Tang Mingjie, Zhang Mingkun, Xia Liangping, Wei Dongshan, Yang Zhongbo, Yan Shihan, Du Chunlei, Cui Hong-Liang

Abstract excerpt

Terahertz absorption spectroscopy based on attenuated total reflection (ATR) from a microfluidic sample cell was designed and implemented to detect gene mutations leading to Huntington's disease (HD). The self-developed compact ATR microfluidic system was employed to detect two groups of base-repeated DNA molecules combined with a terahertz time-domain spectrometer in a marker-free manner. The first group...

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PMID: 32981137
DOI: 10.1002/jbio.202000315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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