Article
Real time hybridization studies by resonant waveguide gratings using nanopattern imaging for Single Nucleotide Polymorphism detection.
Biomedical microdevices - 1 Apr 2014
Bougot-Robin Kristelle, Kodzius Rimantas, Yue Weisheng, Chen Longqing, Li Shunbo, Zhang Xi Xiang, Benisty Henri, Wen Weijia
Abstract excerpt
2D imaging of biochips is particularly interesting for multiplex biosensing. Resonant properties allow label-free detection using the change of refractive index at the chip surface. We demonstrate a new principle of Scanning Of Resonance on Chip by Imaging (SORCI) based on spatial profiles of nanopatterns of resonant waveguide gratings (RWGs) and its embodiment in a fluidic chip for real-time biological studies....
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