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Article

p21 can be a barrier to ferroptosis independent of p53

24 Sept 2020

Abstract excerpt

Traditionally, the p21 protein has been viewed as limiting cancer progression and promoting aging. In contrast, there are reports that p21 can enhance cancer survival and limit tissue damage, depending on the tissue of origin and type of stressor involved. Here, we provide evidence to support these latter two roles of p21 by exploring its ability to regulate ferroptosis. Ferroptosis is a form of cell death that...

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PMID: 32979260
DOI: 10.18632/aging.103961

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