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Inhibition of p21 activates Akt kinase to trigger ROS-induced autophagy and impacts on tumor growth rate

15 Dec 2022

Abstract excerpt

Owing to its ability to induce cellular senescence, inhibit PCNA, and arrest cell division cycle by negatively regulating CDKs as well as being a primary target of p53, p21 is traditionally considered a tumor suppressor. Nonetheless, several reports in recent years demonstrated its pro-oncogenic activities such as apoptosis inhibition by cytosolic p21, stimulation of cell motility, and promoting assembly of...

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PMID: 36522339
DOI: 10.1038/s41419-022-05486-1

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