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Article

DUBbing Ferroptosis in Cancer Cells

15 Apr 2019

Abstract excerpt

Abstract Ferroptosis, a form of iron-dependent, nonapoptotic cell death that is induced by excessive lipid peroxidation, has been recently identified as a new tumor suppression mechanism. In this issue of Cancer Research, Liu and colleagues demonstrate that the deubiquitinase (DUB) OTUB1 is frequently overexpressed in human cancers, and functions to “dub” (trim) the ferroptosis process in cancer cells and...

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PMID: 30987975
DOI: 10.1158/0008-5472.can-19-0487

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