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Article

CoMM-S2: a collaborative mixed model using summary statistics in transcriptome-wide association studies.

Bioinformatics (Oxford, England) - 1 Apr 2020

Yang Yi, Shi Xingjie, Jiao Yuling, Huang Jian, Chen Min, Zhou Xiang, Sun Lei, Lin Xinyi, Yang Can, Liu Jin

Abstract excerpt

MOTIVATION: Although genome-wide association studies (GWAS) have deepened our understanding of the genetic architecture of complex traits, the mechanistic links that underlie how genetic variants cause complex traits remains elusive. To advance our understanding of the underlying mechanistic links, various consortia have collected a vast volume of genomic data that enable us to investigate the role that genetic...

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PMID: 31755899
DOI: 10.1093/bioinformatics/btz880

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