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Article

Increased expression profile of NCSTN, Notch and PI3K/AKT3 in hidradenitis suppurativa

26 Sept 2020

Abstract excerpt

BACKGROUND: In a small number of kindreds with familial hidradenitis suppurativa (HS) different mutations of NCSTN (nicastrin) have been identified. Blocking of NCSTN leads to impairment of the Notch and PI3K/AKT signalling pathway, which is assumed to play a pathogenic role in HS. However, very limited data are available concerning expression levels of these pathway components in HS skin. OBJECTIVES: To analyse...

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PMID: 32978818
DOI: 10.1111/jdv.16962

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