Phenotype of 53 Chinese individuals with nicastrin gene mutations in association with familial hidradenitis suppurativa (acne inversa)

Abstract excerpt

Dear Editor, Hidradenitis suppurativa (HS), also called acne inversa, is a chronic, relapsing, inflammatory skin disorder. It involves mainly the apocrine‐gland‐bearing areas. HS can be sporadic or familial; familial HS is an autosomal–dominant inheritance disease.1 In 2010 Wang et al. first reported that familial HS was related to mutation of γ‐secretase,2 which consists of presenilin, nicastrin, presenilin...

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