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Article

AKT‐dependent hyperproliferation of keratinocytes in familial hidradenitis suppurativa with a NCSTN mutation: a potential role of defective miR‐100‐5p

26 Aug 2019

Abstract excerpt

Dear Editor, Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic inflammatory skin disorder affecting apocrine gland‐bearing areas of the body.1 Although the precise pathogenesis of HS is unclear, genetic mutation may be one important factor. Recently, loss‐of‐function mutations of nicastrin (NCSTN), a subunit of γ‐secretase, have been detected in some patients with familial HS.2,3 In 2016, we...

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PMID: 31448409
DOI: 10.1111/bjd.18460

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AKT‐dependent hyperproliferation of keratinocytes in familial hidradenitis suppurativa with a NCSTN mutation: a potential role of defective miR‐100‐5pPMID 31448409Read ↗

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