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Deficiency of the Tbc1d21 gene causes male infertility with morphological abnormalities of the sperm mitochondria and flagellum in mice

25 Sept 2020

Abstract excerpt

Approximately 2-15% of couples experience infertility, and around half of these cases are attributed to male infertility.We previously identified TBC1D21 as a sterility-related RabGAP gene derived from infertile men.However, the in vivo function of TBC1D21 in male fertility remains unclear.Here, we show that loss of Tbc1d21 in mice resulted in male infertility, characterized by defects in sperm tail structure and...

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PMID: 32976492
DOI: 10.1371/journal.pgen.1009020

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