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Article

The Genetic Defects of N-DRC in Male Infertility.

Clinical genetics - 1 Jan 2026

Qin Jiao, Wang Jinyu, Li Dingming, Li Fuping

Abstract excerpt

The nexin-dynein regulatory complex (N-DRC) is a large protein complex composed of at least 11 subunits (DRC1-DRC11) and plays a crucial role in ciliary and flagellar motility. It links adjacent doublets of microtubules (DMTs) between A and B microtubules, regulating dynein motor activity. Genetic defects in N-DRC subunits lead to primary ciliary dyskinesia (PCD) and abnormal flagellar motility. In recent years,...

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PMID: 41022581
DOI: 10.1111/cge.70081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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