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Article

Resistance to Some But Not Other Dimeric Lindenane Sesquiterpenoid Esters Is Mediated by Mutations in a Plasmodium falciparum Esterase.

ACS infectious diseases - 13 Nov 2020

Butler Joshua H, Baptista Rodrigo P, Valenciano Ana L, Zhou Bin, Kissinger Jessica C, Tumwebaze Patrick K, Rosenthal Philip J, Cooper Roland A, Yue Jian-Min, Cassera Maria B

Abstract excerpt

Unique lindenane sesquiterpenoid dimers from Chloranthecae spp. were recently identified with promising in vitro antiplasmodial activity and potentially novel mechanisms of action. To gain mechanistic insights to this new class of natural products, in vitro selection of Plasmodium falciparum resistance to the most active antiplasmodial compound, chlorajaponilide C, was explored. In all selected resistant clones,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32970404
DOI: 10.1021/acsinfecdis.0c00487
PMCID: PMC11075783

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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