Article
Targeted Next-Generation Sequencing and Allele-Specific Quantitative PCR of Laser Capture Microdissected Samples Uncover Molecular Differences in Mixed Odontogenic Tumors.
The Journal of molecular diagnostics : JMD - 1 Dec 2020
Coura Bruna Pizziolo, Bernardes Vanessa Fátima, de Sousa Sílvia Ferreira, Diniz Marina Gonçalves, Moreira Rennan Garcias, de Andrade Bruno Augusto Benevenuto, Romañach Mario José, Pontes Helder Antônio Rebelo, Gomez Ricardo Santiago, Odell Edward William, Gomes Carolina Cavalieri
Abstract excerpt
The molecular pathogenesis of mixed odontogenic tumors has not been established, and understanding their genetic basis could refine their classification and help define molecular markers for diagnostic purposes. Potentially pathogenic mutations in the component tissues of 28 cases of mixed odontogenic tumors were assessed. Laser capture microdissected tissue from 10 ameloblastic fibromas (AF), 4 ameloblastic...
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