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Article

Effects of long-term in vivo micro-CT imaging on hallmarks of osteopenia and frailty in aging mice.

PloS one - 1 Jan 2020

Scheuren Ariane C, Kuhn Gisela A, Müller Ralph

Abstract excerpt

In vivo micro-CT has already been used to monitor microstructural changes of bone in mice of different ages and in models of age-related diseases such as osteoporosis. However, as aging is accompanied by frailty and subsequent increased sensitivity to external stimuli such as handling and anesthesia, the extent to which longitudinal imaging can be applied in aging studies remains unclear. Consequently, the...

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PMID: 32966306
DOI: 10.1371/journal.pone.0239534
PMCID: PMC7511008

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