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Article

Quantitative micro-CT-derived biomarkers elucidate age-related lung fibrosis in elder mice

30 Oct 2024

Abstract excerpt

BACKGROUND: Idiopathic Pulmonary Fibrosis (IPF), prevalently affecting individuals over 60 years of age, has been mainly studied in young mouse models. The limited efficacy of current treatments underscores the need for animal models that better mimic an aged patient population. We addressed this by inducing pulmonary fibrosis in aged mice, using longitudinal micro-CT imaging as primary readout, with special...

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PMID: 39478545
DOI: 10.1186/s12931-024-03006-7

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