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Article

Inhibiting mitochondrial respiration prevents cancer in a mouse model of Li-Fraumeni syndrome

20 Nov 2016

Abstract excerpt

Li-Fraumeni syndrome (LFS) is a cancer predisposition disorder caused by germline mutations in TP53 that can lead to increased mitochondrial metabolism in patients. However, the implications of altered mitochondrial function for tumorigenesis in LFS are unclear. Here, we have reported that genetic or pharmacologic disruption of mitochondrial respiration improves cancer-free survival in a mouse model of LFS that...

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PMID: 27869650
DOI: 10.1172/jci88668

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