Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hepatitis C cross-genotype immunity and implications for vaccine development.

Scientific reports - 26 Sept 2017

Islam Nazrul, Krajden Mel, Shoveller Jean, Gustafson Paul, Gilbert Mark, Wong Jason, Tyndall Mark W, Janjua Naveed Zafar

Abstract excerpt

While about a quarter of individuals clear their primary hepatitis C (HCV) infections spontaneously, clearance (spontaneous or treatment-induced) does not confer sterilizing immunity against a future infection. Since successful treatment does not prevent future infections either, an effective vaccine is highly desirable in preventing HCV (re)infection. However, development of an effective vaccine has been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Neutralizing
Share to Cross Protection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis C

Share to Hepatitis C Antibodies

Share to Immunization, Secondary

Share to Vaccination

Share to Viral Envelope Proteins

Share to Viral Hepatitis Vaccines

Source

Open in PubMed Open full text

Identifiers

PMID: 28951612
DOI: 10.1038/s41598-017-10190-8
PMCID: PMC5615075

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hepatitis C cross-genotype immunity and implications for vaccine development.PMID 28951612Read ↗

Cross-genotype immunity to hepatitis C virus.Semantic proximity Read ↗

Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus.Semantic proximity Read ↗

Role of HVR1 sequence similarity in the cross-genotypic neutralization of HCV.Semantic proximity Read ↗

Hepatitis C Virus Genetic Variability, Human Immune Response, and Genome Polymorphisms: Which Is the Interplay?Semantic proximity Read ↗

Protection against chronic hepatitis C virus infection after rechallenge with homologous, but not heterologous, genotypes in a chimpanzee model.Semantic proximity Read ↗

A Hepatitis C Virus (HCV) Vaccine Comprising Envelope Glycoproteins gpE1/gpE2 Derived from a Single Isolate Elicits Broad Cross-Genotype Neutralizing Antibodies in HumansSemantic proximity Read ↗

From Structural Studies to HCV Vaccine Design.Semantic proximity Read ↗

Repeated exposure to heterologous hepatitis C viruses associates with enhanced neutralizing antibody breadth and potencySemantic proximity Read ↗

Evidence for cross-genotype neutralization of hepatitis C virus pseudo-particles and enhancement of infectivity by apolipoprotein C1.Semantic proximity Read ↗

Hepatitis C virus. The importance of viral heterogeneity.Semantic proximity Read ↗

Cross-reactivity and clinical impact of the antibody response to hepatitis C virus second envelope glycoprotein (E2).Semantic proximity Read ↗

The broad assessment of HCV genotypes 1 and 3 antigenic targets reveals limited cross-reactivity with implications for vaccine design.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.