Article
Limitations of Detecting Genetic Variants from the RNA Sequencing Data in Tissue and Fine-Needle Aspiration Samples.
Thyroid : official journal of the American Thyroid Association - 1 Apr 2021
Kaya Cihan, Dorsaint Princesca, Mercurio Stephanie, Campbell Alexander M, Eng Kenneth Wha, Nikiforova Marina N, Elemento Olivier, Nikiforov Yuri E, Sboner Andrea
Abstract excerpt
Background: Genetic profiling of resected tumor or biopsy samples is increasingly used for cancer diagnosis and therapy selection for thyroid and other cancer types. Although mutations occur in cell DNA and are typically detected using DNA sequencing, recent attempts focused on detecting pathogenic variants from RNA. The aim of this study was to determine the completeness of capturing mutations using RNA...
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