Plasma biopsy by Tag-sequencing: an acceptable alternative to tumor tissue profiling in non-small-cell lung cancer.

Abstract excerpt

Tag-sequencing is a modified next-generation sequencing (NGS) approach wherein targeted regions are tagged with unique molecular identifiers enabling error-free detection of rare genomic alterations. We aimed to perform this high- fidelity sequencing to identify actionable variants from the plasma of lung cancer patients. Targeted sequencing was performed from plasma-derived cell-free nucleic acid in twenty-one...

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