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Epigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes

16 Sept 2020

Abstract excerpt

Metformin is the first-line pharmacotherapy for managing type 2 diabetes (T2D). However, many patients with T2D do not respond to or tolerate metformin well. Currently, there are no phenotypes that successfully predict glycemic response to, or tolerance of, metformin. We explored whether blood-based epigenetic markers could discriminate metformin response and tolerance by analyzing genome-wide DNA methylation in...

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PMID: 32938793
DOI: 10.1126/scitranslmed.aaz1803

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