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Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver

21 Sept 2017

Abstract excerpt

Given that metformin is the most common pharmacological therapy for type 2 diabetes, understanding the function of this drug is of great importance. Hepatic metformin transporters are responsible for the pharmacologic action of metformin. However, epigenetics in genes encoding metformin transporters has not been fully elucidated. We examined the DNA methylation of these genes in the liver of subjects with type 2...

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PMID: 28947922
DOI: 10.1186/s13148-017-0400-0

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