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Type 2 diabetes and leucocyte DNA methylation: an epigenome-wide association study in over 1,500 older adults.

Diabetologia - 1 Jan 2016

Florath Ines, Butterbach Katja, Heiss Jonathan, Bewerunge-Hudler Melanie, Zhang Yan, Schöttker Ben, Brenner Hermann

Abstract excerpt

AIMS/HYPOTHESIS: Development of type 2 diabetes depends on environmental and genetic factors. We investigated the epigenome-wide association of prevalent diabetes with DNA methylation (DNAm) in peripheral blood. METHODS: DNAm was measured in whole blood with the Illumina Infinium HumanMethylation450 BeadChip in two subsamples of participants from the ESTHER cohort study. Cohort 1 included 988 participants, who...

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PMID: 26433941
DOI: 10.1007/s00125-015-3773-7

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TXNIP

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