Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular cloning and functional characterization of porcine cyclic GMP-AMP synthase.

Molecular immunology - 1 Jun 2015

Wang Jiang, Chu Beibei, Du Lili, Han Yingqian, Zhang Xuemei, Fan Shuangshuang, Wang Yueying, Yang Guoyu

Abstract excerpt

Cyclic GMP-AMP synthase (cGAS), which belongs to the nucleotidyltransferase family, recognizes cytosolic DNA and induces the type I interferon (IFN) pathway through the synthesis of the second messenger cGAMP. In this study, porcine cGAS (p-cGAS) was identified and its tissue distribution, subcel...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cattle
Share to Endoplasmic Reticulum
Share to Interferon-beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Membranes

Share to Nucleotidyltransferases

Share to Organ Specificity

Share to Sequence Homology, Amino Acid

Source

Identifiers

PMID: 25765883
DOI: 10.1016/j.molimm.2015.02.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25765883-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular cloning and functional characterization of porcine cyclic GMP-AMP synthase.PMID 25765883Read ↗

Characterization of cGAS homologs in innate and adaptive mucosal immunities in zebrafish gives evolutionary insights into cGAS‐STING pathwaySemantic proximity Read ↗

PRV UL13 inhibits cGAS–STING-mediated IFN-β production by phosphorylating IRF3Semantic proximity Read ↗

cGAS goes viral: A conserved immune defense system from bacteria to humansSemantic proximity Read ↗

Chicken cGAS Senses Fowlpox Virus Infection and Regulates Macrophage Effector FunctionsSemantic proximity Read ↗

cGLRs are a diverse family of pattern recognition receptors in animal innate immunitySemantic proximity Read ↗

cGAMP the travelling messengerSemantic proximity Read ↗

Regulation of cGAS‐Mediated Immune Responses and ImmunotherapySemantic proximity Read ↗

Cyclic GMP-AMP synthase- Stimulator of Interferon Genes Signaling and their Agonistic / Antagonistic ValuesSemantic proximity Read ↗

Advances in cGAS-STING Signaling Pathway and DiseasesSemantic proximity Read ↗

Crystal structures of porcine STINGCBD–CDN complexes reveal the mechanism of ligand recognition and discrimination of STING proteinsSemantic proximity Read ↗

Structural and functional analyses of DNA-sensing and immune activation by human cGAS.Semantic proximity Read ↗

Viral cGAMP nuclease reveals the essential role of DNA sensing in protection against acute lethal virus infectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.