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Seneca Valley virus 3C pro antagonizes type I interferon response by targeting STAT1-STAT2-IRF9 and KPNA1 signals

11 Oct 2023

Abstract excerpt

ABSTRACT The Seneca Valley virus (SVV) is an emerging pathogen that causes vesicular disease in pigs, posing a threat to the pork industry. The type I interferon (IFN) signaling pathway is the major defense mechanism of host innate immune responses, and SVV has developed numerous strategies to antagonize the IFN signaling and promote viral replication. However, the molecular mechanisms by which SVV affects IFN...

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PMID: 37819133
DOI: 10.1128/jvi.00727-23

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