Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Whole exome sequencing reveals BAP1 somatic abnormalities in mesothelioma in situ.

Lung cancer (Amsterdam, Netherlands) - 1 Nov 2020

Dacic Sanja, Roy Somak, Lyons Maureen A, von der Thusen Jan H, Galateau-Salle Francoise, Churg Andrew

Abstract excerpt

OBJECTIVES: We have recently described the first cases of mesothelioma in situ, identified as a pure surface population of mesothelial cells that have lost BAP1 nuclear staining, in the setting of no clinically/radiologically demonstrable mesothelial tumor. These cases have a high propensity to develop invasive mesothelioma. The genetic events that lead to the development of mesothelioma in situ are unknown, nor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Exome Sequencing
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lung Neoplasms

Share to Mesothelioma

Share to Myasthenia Gravis and Thymoma

Share to Occupational and environmental lung diseases

Share to Tumor Suppressor Proteins

Share to Ubiquitin Thiolesterase

Source

Identifiers

PMID: 32932212
DOI: 10.1016/j.lungcan.2020.09.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole exome sequencing reveals BAP1 somatic abnormalities in mesothelioma in situ.PMID 32932212Read ↗

BAP1 mutation is a frequent somatic event in peritoneal malignant mesothelioma.Semantic proximity Read ↗

Clinical and Pathologic Phenotyping of Mesotheliomas Developing in Carriers of Germline BAP1 Mutations.Semantic proximity Read ↗

Genomics and Epigenetics of Malignant MesotheliomaSemantic proximity Read ↗

Malignant mesothelioma in situ: diagnostic and clinical considerations.Semantic proximity Read ↗

BAP1, a tumor suppressor gene driving malignant mesotheliomaSemantic proximity Read ↗

Prospective Analysis of Mesotheliomas in Subjects With BAP1 Cancer Syndrome: Clinical Characteristics and Epigenetic Correlates of DiseaseSemantic proximity Read ↗

BAP1 Is Altered by Copy Number Loss, Mutation, and/or Loss of Protein Expression in More Than 70% of Malignant Peritoneal Mesotheliomas.Semantic proximity Read ↗

High Incidence of Somatic BAP1 alterations in sporadic malignant mesothelioma.Semantic proximity Read ↗

Molecular characterization of pleomorphic mesothelioma: a multi-institutional study.Semantic proximity Read ↗

Malignant cells from pleural fluids in malignant mesothelioma patients reveal novel mutations.Semantic proximity Read ↗

Whole-exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma.Semantic proximity Read ↗

Peritoneal papillary mesothelioma in situ: BAP1 mutation with indolent behavior for 15 years.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.