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Article

Molecular characterization of pleomorphic mesothelioma: a multi-institutional study.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 2022

Roy Somak, Galateau-Sallé Françoise, Le Stang Nolwenn, Churg Andrew, Lyons Maureen A, Attanoos Richard, Dacic Sanja

Abstract excerpt

The molecular alterations of pleomorphic mesotheliomas are largely unknown. In the present study, we performed whole-exome sequencing (WES) on 24 pleomorphic mesotheliomas in order to better characterize the molecular profile of this rare histologic variant. BAP1 protein expression and CDKN2A deletion by FISH were also evaluated. Significantly mutated genes included BAP1 (35%), NF2 (13%), LATS2 (8%), TP53 (5%),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34531524
DOI: 10.1038/s41379-021-00900-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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